Product Name :
Pyrrolidino PAF C-16
Description:
Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16 with hypotensive action . Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte – derived macrophages. PAF have potent hypotensive activity. C16-PAF was about three times more potent than C18-PAF in the activity of releasing serotonin . Pyrrolidino PAF C-16, a synthetic analog of PAF C-16, is a potent mediator of PAF-like activities, including hypotension and platelet aggregation . In male Wistar rats, Pyrrolidino PAF C-16 dose-dependently decreased blood pressure and the duration of the hypotension was also dose-dependent. Pyrrolidino PAF C-16 was 3-10 times more potent than natural PAF in the hypotensive activity .
CAS:
91021-63-5
Molecular Weight:
549.72
Formula:
C28H56NO7P
Chemical Name:
1-(2-{[(2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl phosphonato]oxy}ethyl)-1-methylpyrrolidin-1-ium
Smiles :
CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+]1(C)CCCC1)OC(C)=O
InChiKey:
QBLLCUIJMABRFJ-MUUNZHRXSA-N
InChi :
InChI=1S/C28H56NO7P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-19-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3)20-17-18-21-29/h28H,4-26H2,1-3H3/t28-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Polysorbate 20} MedChemExpress|{Polysorbate 20} {Biochemical Assay Reagents}|{Polysorbate 20} Technical Information|{Polysorbate 20} In stock|{Polysorbate 20} custom synthesis|{Polysorbate 20} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16 with hypotensive action . Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte – derived macrophages. PAF have potent hypotensive activity. C16-PAF was about three times more potent than C18-PAF in the activity of releasing serotonin . Pyrrolidino PAF C-16, a synthetic analog of PAF C-16, is a potent mediator of PAF-like activities, including hypotension and platelet aggregation .{{Lopinavir} medchemexpress|{Lopinavir} Anti-infection|{Lopinavir} Technical Information|{Lopinavir} Formula|{Lopinavir} custom synthesis|{Lopinavir} Autophagy} In male Wistar rats, Pyrrolidino PAF C-16 dose-dependently decreased blood pressure and the duration of the hypotension was also dose-dependent.PMID:23381601 Pyrrolidino PAF C-16 was 3-10 times more potent than natural PAF in the hypotensive activity .|Product information|CAS Number: 91021-63-5|Molecular Weight: 549.72|Formula: C28H56NO7P|Chemical Name: 1-(2-{[(2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl phosphonato]oxy}ethyl)-1-methylpyrrolidin-1-ium|Smiles: CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+]1(C)CCCC1)OC(C)=O|InChiKey: QBLLCUIJMABRFJ-MUUNZHRXSA-N|InChi: InChI=1S/C28H56NO7P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-19-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3)20-17-18-21-29/h28H,4-26H2,1-3H3/t28-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|