CD45 Recombinant Rabbit Monoclonal Antibody [JE03-05]

Product Name :
CD45 Recombinant Rabbit Monoclonal Antibody [JE03-05]

Predicted band size :
147 kDa

Observed band size :
200 kDa

Synonyms:
B220 antibody CD 45 antibody CD45 antibody CD45 antigen antibody CD45R antibody GP180 antibody L-CA antibody LCA antibody Leukocyte common antigen antibody loc antibody 展开

Function :
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA). The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.

Antibody Type:
Recombinant Rabbit monoclonal Antibody

Immunogen :
Recombinant protein within Human CD45 aa 1,210-1,306 / 1,306.Dapsone

Species reactivity:
Human

Verify application:
WB, IHC-P, FC, IF-Tissue, mIHC

Coupling :
unconjugated

Clone number:
JE03-05

RRID:
AB_3071060

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at +4℃ after thawing.Imipramine hydrochloride Aliquot store at -20℃.PMID:23310954 Avoid repeated freeze / thaw cycles.

Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 147 kDa

Positive control :
Jurkat cell lysates, human tonsil tissue, human colon cancer tissue, human spleen cancer tissue, Jurkat.

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