Product Name :
CD327 Mouse Monoclonal Antibody [3C11C12G1]
Predicted band size :
Observed band size :
Synonyms:
CD327 antibody CD33 antigen-like 1 antibody CD33L antibody CD33L1 antibody CD33L2 antibody CDw327 antibody OB-BP1 antibody OBBP1 antibody Obesity-binding protein 1 antibody Sialic acid-binding Ig-like lectin 6 antibody 展开
Function :
SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Purified recombinant fragment of human CD327 (AA: extra 27-347) expressed in E. Coli.
Species reactivity:
Human
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
3C11C12G1
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
4℃; -20℃ for long term storage.Ritonavir
Storage buffer solution:
Purified antibody in PBS with 0.Tafamidis 05% sodium azide.PMID:24293312
Subtype:
IgG2b
Purification method :
Protein G affinity purified.
ELTSA :
Molecular weight :
50kDa
Positive control :
HL-60 cells cervical cancer rectum cancer