Product Name :
CD276 Mouse Monoclonal Antibody [C10-A1]
Predicted band size :
Observed band size :
Synonyms:
4Ig B7 H3 antibody 4Ig-B7-H3 antibody AU016588 antibody B7 H3 antibody B7 homolog 3 antibody B7-H3 antibody B7H3 antibody B7RP-2 antibody CD_antigen=CD276 antibody CD276 antibody 展开
Function :
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 Immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein
Species reactivity:
Human
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
C10-A1
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.Bepridil hydrochloride
Storage buffer solution:
Purified antibody in PBS with 0.Rebaudioside M 05% sodium azide.PMID:24834360
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
57 kDa
Positive control :
CD276-hIgGFc transfected HEK293 cell lysate, human cervical cancer tissue, human ovarian cancer tissue, PC-3.