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Xestospongin C

CAS No. : 88903-69-9

Biological Activity：Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca²⁺ signaling in neuronal and nonneuronal cells^[2]^[3].

Research Area：Neurological Disease

Targets：Calcium Channel|Apoptosis

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Benidipine hydrochloride;Calpeptin;Lobetyolin;CaV1.3 antagonist-1;14-Deoxyandrographolide;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9

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