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Vimirogant hydrochloride

Biological Activity：Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; IC₅₀=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC₅₀=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research^[2].

Research Area：Inflammation/Immunology

Targets：ROR

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;

Related Small Molecules:RORγt inhibitor 1;GNE-6468;SR3335;RORγt inverse agonist 30;GNE-0946;RORγt inverse agonist 13;SR2211;Bevurogant;ROR agonist-1;RORγt Inverse agonist 8;CD12681;S18-000003;RORγt inhibitor 2;XY018;RORγt inverse agonist 29;SR1001;Cedirogant;SHR168442;ARN-6039;A-9758;Cintirorgon;Nobiletin;TAK-828F;RORγt inverse agonist 26;GSK805;PF-06747711;Zilovertamab;(±)-ML 209

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