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Vercirnon

CAS No. : 698394-73-9

Biological Activity：Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca²⁺ mobilization and chemotaxis on Molt-4 cells with IC₅₀ values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC₅₀s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC₅₀ values of 2.8 and 2.6 nM, respectively.

Research Area：Inflammation/Immunology|Endocrinology

Targets：CCR

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Clinical Compound Library;Small Molecule Immuno-Oncology Compound Library;Drug Repurposing Compound Library;Endocrinology Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Human Metabolite Library;Anti-Pulmonary Fibrosis Compound Library;Chemokine Compound Library;

Related Small Molecules:LMD-009;PF-04634817 succinate;CKLF1-C27;Bindarit;CCR6 antagonist 1;CCR6 inhibitor 1;CCR4-351 hydrochloride;BI 639667;ML604086;CCR4 antagonist 3-1;AZD2423;AZD2098;AZD-1678;R243;RS102895 hydrochloride;Vicriviroc maleate;BMS-639623;AZD-4818;INCB 3284 dimesylate;Maceneolignan H;CKLF1-C27 TFA;CCR3 antagonist 1;C-021;INCB3344;RPT193

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