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(S,R,S)-AHPC TFA
CAS No. : 1631137-51-3
Biological Activity：(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
Research Area：Cancer
Targets：Ligands for E3 Ligase
Related Small Molecules:CRBN modulator-1;cIAP1 ligand 4;(S,R,S)-AHPC-Me;cIAP1 ligand 2;E3 ligase Ligand 23;VH032;BC-1215;VH032-cyclopropane-F;KB02-COOH;N-Boc-SBP-0636457-OH;SJPYT-195;TD-106;CC-885;VH032-OH
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