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(S,R,S)-AHPC-Me
CAS No. : 1948273-02-6
Biological Activity：(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].
Research Area：Cancer
Targets：Ligands for E3 Ligase
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Cancer Compound Library;Ubiquitination Compound Library;Anti-Prostate Cancer Compound Library;E3 Ligase Ligand Library;
Related Small Molecules:(S,R,S)-AHPC TFA;CRBN modulator-1;cIAP1 ligand 4;cIAP1 ligand 2;E3 ligase Ligand 23;VH032;BC-1215;VH032-cyclopropane-F;KB02-COOH;N-Boc-SBP-0636457-OH;SJPYT-195;TD-106;CC-885;VH032-OH
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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