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SR12813
CAS No. : 126411-39-0
Biological Activity：SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM[2]. SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR)[3].
Research Area：Metabolic Disease
Targets：Autophagy|HMG-CoA Reductase (HMGCR)
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Autophagy Compound Library;Ferroptosis Compound Library;Anti-Cancer Metabolism Compound Library;Lipid Metabolism Compound Library ;Targeted Diversity Library;Nuclear Receptor Compound Library;
Related Small Molecules:β-Amyrin acetate;Cerivastatin;Meglutol;Hesperetin 7-O-glucoside;Monacolin J;QH536;β-Amyrin palmitate;HMG499;Clinofibrate;Mevastatin;S-2E
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