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SCH79797 dihydrochloride
CAS No. : 1216720-69-2
Biological Activity：SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes[2][3][4].
Research Area：Cardiovascular Disease
Targets：Protease Activated Receptor (PAR)|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;GPCR/G Protein Compound Library;Anti-Cardiovascular Disease Compound Library;Human Metabolite Library;Coagulation and Anti-coagulation Compound Library;
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