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PTC299
CAS No. : 1256565-36-2
Biological Activity：PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies[2].
Research Area：Cancer
Targets：Dihydroorotate Dehydrogenase|DNA/RNA Synthesis|VEGFR
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