For research use only. We do not sell to patients.
PROTAC EGFR degrader 7
Biological Activity：PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC50 of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI–H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research.
Research Area：Cancer
Targets：EGFR|PROTACs|Apoptosis
Related Small Molecules:Physalin A;Bomedemstat ditosylate;PROTAC Sirt2 Degrader-1;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;NSC81111;BJE6-106;Dinaciclib;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;Ecteinascidin 770;MDM2-p53-IN-15;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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Structurally and synthetically diverse biologically active compounds；
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