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PK68

CAS No. : 2173556-69-7

Biological Activity：PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis.

Research Area：Cancer|Inflammation/Immunology

Targets：RIP kinase

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;Anti-Cancer Compound Library;Orally Active Compound Library;Protein-protein Interaction Inhibitor Library;

Related Small Molecules:RIPA-56;RIPK3-IN-2;GSK2983559 free acid;AV123;RIPK1-IN-8;RIP2 kinase inhibitor 2;RIP2 Kinase Inhibitor 4;GSK-872;RIPK-IN-4;TP-030-2;OD36;TP-030-1;RIPK2-IN-2;GSK3145095;Necrostatin 2;RIPK1-IN-4;RIPK1-IN-15;GSK-843;(Rac)-GSK547;RIPK2-IN-1;RIP2 kinase inhibitor 1;Kongensin A;PROTAC RIPK degrader-6;RIPK1-IN-10

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