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p-nitro-Pifithrin-α
CAS No. : 389850-21-9
Biological Activity：p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4].
non-alcoholic fatty liver disease[2][3].
Research Area：Infection|Metabolic Disease
Targets：MDM-2/p53|Caspase|TGF-β Receptor
Related Small Molecules:MDM2-p53-IN-15;ML347;Dehydrocorydaline;MC-VC-PABC-SP 141;LDN193189 (GMP);TGFβRI-IN-4;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;ALK5-IN-6;TGFβ-IN-1;Z-DEVD-AMC;MD-224;Mutant p53 modulator-1;MDM2/4-p53-IN-2;MX69;RG7112;ML132;MMRi62;Anticancer agent 50;NSC59984;L67;AKN-028 acetate;Pifithrin-β hydrobromide;Ivaltinostat formic;GEM-5
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