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NRX-252114
CAS No. : 2763260-39-3
Biological Activity：NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation.
Research Area：Cancer
Targets：β-catenin|Molecular Glues
Related Small Molecules:CDK8-IN-11 hydrochloride;(R)-CR8 trihydrochloride;(E)-Ferulic acid-d3;Avadomide;Voclosporin;Laduviglusib (GMP);NRX-252262;Toxoflavin;TMX-4100;HLY78;CCT031374 hydrobromide;β-catenin-IN-4;Tasisulam;FPFT-2216;Triptonide;Astragaloside I;HQ461;β-catenin-IN-3;NLS-StAx-h;Cyclosporin A;FzM1.8;KY19382
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