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NKP-1339
CAS No. : 197723-00-5
Biological Activity:NKP-1339 (IT-139; KP-1339) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. NKP-1339 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. NKP-1339 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu.
Research Area:Cancer
Targets:DNA/RNA Synthesis|Apoptosis
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Anti-Lung Cancer Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Ametantrone;BJE6-106;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib
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