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Mitoguazone
CAS No. : 459-86-9
Biological Activity：Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin’s and non-Hodgkin’s lymphoma treatment[2][3][4].
Research Area：Cancer|Infection
Targets：HIV|Apoptosis
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Antiviral Compound Library;Drug Repurposing Compound Library;Anti-Breast Cancer Compound Library;Anti-Blood Cancer Compound Library;Rare Diseases Drug Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;HIV-1 TAT (48-60);Ecteinascidin 770;MDM2-p53-IN-15;Seletracetam lithium;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;HIV-IN-2;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9
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