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Methotrexate-d3

CAS No. : 432545-63-6

Biological Activity：Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)^[2]^[3].

Research Area：Cancer|Inflammation/Immunology

Targets：DNA/RNA Synthesis|ADC Cytotoxin|Antifolate|Apoptosis

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Sandramycin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Ametantrone;BJE6-106;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9

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