For research use only. We do not sell to patients.
Maytansinol
CAS No. : 57103-68-1
Biological Activity：Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.
Target: Microtubule/Tubulin
in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.
Research Area：Cancer
Targets：Microtubule/Tubulin|ADC Cytotoxin|Apoptosis
Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Natural Product Library;Toxins for Antibody-Drug Conjugate Research Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Cytoskeleton Compound Library;Alkaloids Library;Anti-Lung Cancer Compound Library;Microbial Metabolite Library;Anti-Cancer Natural Product Library;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Sandramycin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Tirbanibulin dihydrochloride;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Tilavonemab;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
