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Malotilate

CAS No. : 59937-28-9

Biological Activity：Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC₅₀=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes^[2].

Research Area：Cancer

Targets：Lipoxygenase

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Ferroptosis Compound Library;NMPA-Approved Drug Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Lipid Metabolism Compound Library ;Targeted Diversity Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;

Related Small Molecules:COX-2/5-LOX-IN-3;A-69412;5-LOX-IN-1;Atreleuton;S-(+)-Marmesin;Phenidone;2-TEDC;BW B70C;ALOX15-IN-2;PGS-IN-1;ALOX15-IN-1;Ro 3-1314;Isothymusin;REV 5901;Indirubin-3′-monoxime;S-2474;Enazadrem;RWJ 63556;LY 178002;Xanthatin;CAY10698;Psoralidin;FPL 62064;11-​Keto-​beta-​boswellic acid;Tepoxalin;β-Boswellic acid;Masoprocol;CJ-13,610

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