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Lifitegrast sodium

CAS No. : 1119276-80-0

Biological Activity：Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease.

Research Area：Inflammation/Immunology

Targets：Integrin

Related Small Molecules:GRGDSPK;Integrin Binding Peptide;Cyclo(Arg-Gly-Asp-D-Phe-Cys);Zaurategrast ethyl ester sulfate;HSDVHK-NH2;TC-I 15;α2β1 Integrin Ligand Peptide;Integrin modulator 1;Veltuzumab;GRGDSP TFA;Cyclo(-RGDfK) TFA;Zalunfiban;K34c;THI0019;RGD;Arg-Gly-Asp-Ser (TFA);BIRT 377;αvβ1 integrin-IN-1;RGD-4C;LXW7;Fradafiban;Firategrast;EILEVPST;Valategrast hydrochloride

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