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KB02-JQ1
CAS No. : 2384184-44-3
Biological Activity：KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1.
Research Area：Cancer
Targets：Epigenetic Reader Domain|PROTACs
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;RVX-297;BRD4 Inhibitor-19;UNC6349 (Ket2);PROTAC VEGFR-2 degrader-2;Curcumin;GSK6853;dTAGV-1-NEG;CCT367766 formic;GSK4028;SR-0813;HDAC6 degrader-1;PROTAC Axl Degrader 2;Inobrodib;PhosTAC7;MS98;Apabetalone;OF-1;I-CBP112;JPS014;PROTAC PARP1 degrader;A-485;MD-224;PLX51107;FKBP12 PROTAC dTAG-7;I-BET151;SJ10542;MS8815;GSK040
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