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IRL 2500

CAS No. : 169545-27-1

Biological Activity：IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC₅₀ values of 1.3 and 94 nM for ET_B and ET_A receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

Research Area：Cardiovascular Disease

Targets：Endothelin Receptor

Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Anti-Cardiovascular Disease Compound Library;Neurotransmitter Receptor Compound Library;Angiogenesis-Related Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:BQ-788;[Asn18] Endothelin-1, human;Endothelin-3, human, mouse, rabbit, rat TFA;Sarafotoxin S6c;Sarafotoxin S6a;ANP (1-30), frog;IRL-1620 TFA;Tezosentan;ACT-373898;Ro 46-2005;Ro 46-8443;[Ala2] Endothelin-3, human;ZD-1611;PD-159020;Aminaftone;Aprocitentan-d4;Endothelin 1 (swine, human);Atrial Natriuretic Peptide (ANP) (1-28), rat;Carperitide acetate;[Ala1,3,11,15]-Endothelin (53-63) (TFA);Sparsentan-d5;BQ-123 TFA

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