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GSK-25
CAS No. : 874119-56-9
Biological Activity：GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 μM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 µM for CYP2C9, CYP2D6, CYP3A4, respectively).
Research Area：Cardiovascular Disease
Targets：ROCK|Ribosomal S6 Kinase (RSK)
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus; Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Stem Cell Signaling Compound Library;TGF-beta/Smad Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Ripasudil free base;RSK2-IN-3;Eudesmin;PF-4950834;RSK4-IN-1;FMK-MEA;ROCK-IN-4;AT13148;LX7101;Y-27632 dihydrochloride;RKI-1447;LY-2584702 hydrochloride;Carnosol;Pluripotin;SM1-71;DD1;AS1892802;AT7867;SB-772077B dihydrochloride;BDP5290;AD80;PF-4708671;Fasudil;3-(4-Pyridyl)indole;GSK429286A;Verosudil;CRT0066854
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