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GNF362

CAS No. : 1003019-41-7

Biological Activity：GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb) with an IC₅₀ of 9 nM. GNF362 also inhibits Itpka and Itpkc with IC₅₀ values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3’ kinase B (Itpkb) is a Ca²⁺-dependent kinase, which phosphorylates the 3’ position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4].

Research Area：Inflammation/Immunology

Targets：Phosphatase

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Metabolism/Protease Compound Library;Orally Active Compound Library;Phosphatase Inhibitor Library;Anti-Pulmonary Fibrosis Compound Library;

Related Small Molecules:ZLDI-8;Uralenol;SHP504;Trimyristin;SHP099 hydrochloride;MY10;PTP1B-IN-3 diammonium;Calyculin A;LMPTP inhibitor 1 dihydrochloride;[pTyr5] EGFR (988-993) (TFA);RMC-3943;AS1949490;PGAM1-IN-1;TD52 dihydrochloride;bpV(phen);EDP-305;CCT007093;(E/Z)-Icerguastat;ARL67156 trisodium;Cytostatin;SHP394;PTP1B-IN-4;EWP 815;PTP1B-IN-2;SHP389;NSC 663284;PSB-06126

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