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Furamidine dihydrochloride
CAS No. : 55368-40-6
Biological Activity：Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent[2][3].
Research Area：Cancer|Infection|Inflammation/Immunology
Targets：Phosphodiesterase (PDE)|Parasite|Histone Methyltransferase
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Blood Cancer Compound Library;Antiparasitic Compound library;Neurodegenerative Disease-related Compound Library;Targeted Diversity Library;Anti-Colorectal Cancer Compound Library ;Human Metabolite Library;
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