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Flumatinib mesylate
CAS No. : 895519-91-2
Biological Activity：Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model[2].
Research Area：Cancer
Targets：Bcr-Abl|c-Kit|PDGFR
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Reprogramming Compound Library;Anti-COVID-19 Compound Library;NMPA-Approved Drug Library;Cytoskeleton Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Anti-Blood Cancer Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;FDA-Approved Anticancer Drug Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:AT9283;Bafetinib;Pivanex;Henatinib;SNIPER(ABL)-039;c-Kit-IN-5-1;IHMT-TRK-284;PDGFRα/FLT3-ITD-IN-2;PP58;Chiauranib;Zeteletinib;SNIPER(ABL)-049;Olverembatinib;Pexidartinib;ENMD-2076 Tartrate;GNF-2;AZD2932;CT-721;SNIPER(ABL)-015;GNF-5;AC710 Mesylate;Tyrosine kinase-IN-1
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