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ELN318463
CAS No. : 851600-86-7
Biological Activity：ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1[2].
Research Area：Neurological Disease
Targets：γ-secretase
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:γ-Secretase modulator 4;Crenigacestat;Aβ42-IN-1 free base;Fosciclopirox;JNJ-40418677;gamma-secretase modulator 3;γ-Secretase modulator 11 hydrochloride;γ-Secretase modulator 12;Aβ42-IN-2;DAPT (GMP);BPN-15606;LY-411575 (isomer 3);BMS 433796;YO-01027 (GMP);BI-1408;Nirogacestat dihydrobromide;gamma-secretase modulator 1 hydrochloride;MRK-560;Semagacestat;Begacestat;GSM-1;Compound E;L-685458
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