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DS89002333
Biological Activity：DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM. DS89002333 shows good anti-tumor activity in an FL-HCC patient-derived xenograft model (expressing the DNAJB1-PRKACA fusion gene). DS89002333 can be used in study of fibrolamellar hepatocellular carcinoma (FL-HCC).
Research Area：Cancer
Targets：PKA
Related Small Molecules:PKI 14-22 amide,myristoylated TFA;Staurosporine;Malantide;Rp-8-CPT-cAMPS sodium;PF-4950834;Warangalone;STAD 2;AT13148;CCG215022;KT5720;8-Bromo-cAMP sodium salt;Bilobetin;Jaspamycin;UCN-02;H-8 dihydrochloride;AT7867;H-9 Dihydrochloride;Fasudil;Sp-cAMPS sodium salt;PKI(5-22)amide;8-pCPT-2′-O-Me-cAMP-AM;Metadoxine;Kemptide;H-89;Bucladesine sodium
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Structurally and synthetically diverse biologically active compounds；
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