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DI-1859
CAS No. : 2247061-09-0
Biological Activity：DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage.
Research Area：Cardiovascular Disease
Targets：E1/E2/E3 Enzyme
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:UBE2T/FANCL-IN-1;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;MD-224;MX69;RG7112;Teslexivir;TRAF6 peptide;AM-8735;NAcM-OPT;RO-5963;SENP1-IN-3;Avadomide;M435-1279;MI-1061;HB007;Ubiquitination-IN-1;Milademetan;EN219;Nutlin-3;NSC624206;Hydrocotarnine;TAK-243;PYR-41;SZL P1-41;Siremadlin;BRD5529;SMIP004
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