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COX-2/5-LOX-IN-1
CAS No. : 2410384-50-6
Biological Activity：COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively.
Research Area：Inflammation/Immunology
Targets：COX
Related Small Molecules:Akt/NF-κB/JNK-IN-1;COX-2/5-LOX-IN-3;Ampyrone;COX-2-IN-24;Zaltoprofen-d7;α-Vitamin E-d6;1-Hydroxy-ibuprofen;Asaraldehyde;(-)-Epicatechin;20(S)-Ginsenoside Rg3;Ginsenoside Rd;Nimesulide D5;S-(+)-Marmesin;Tazofelone;Catechin-13C3;Diclofenac-d4;Proglumetacin;Ethoxycoronarin D;Phenidone;Iguratimod;Fenbufen-d9;COX-2-IN-6;Anti-inflammatory agent 9;Pentagamavunon-1;Aceclofenac
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