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Chalcones A-N-5

CAS No. : 2756846-09-8

Biological Activity：Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC₅₀ > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD.

Research Area：Cancer

Targets：Ferroptosis

Related Small Molecules:CIL56;DB0614;Ciclopirox-d11;Ciclopirox olamine;Curcumin;(-)-Epicatechin;Eugenol-d3;Artemisinin-d3;MMRi62;UAMC-3203;L-Glutamic acid-15N,d5;Pifithrin-β hydrobromide;PD146176;Roxadustat;Matrine;Liproxstatin-1;Hemin;L-Glutamic acid monosodium salt;Acetylcysteine-d3;Pifithrin-α hydrobromide

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