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CH5138303
CAS No. : 959763-06-5
Biological Activity：CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90α, with Kd of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC50 values of 0.098 and 0.066 μM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%). CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model[2].
Research Area：Cancer|Infection
Targets：HSP
Related Small Molecules:6BrCaQ;116-9e;Paeoniflorin;HDAC/HSP90-IN-4;Debio 0932;MKT-077;Ethoxyquin;Cemdomespib;Apatorsen;HS-131;Pimitespib;NCT-58;MPC-0767;Retaspimycin;BOLD-100;Onalespib;HSP90-IN-12;Palmitic acid-1-13C;Palmitic acid-d3;Feretoside;Palmitic acid-d9;Palmitic acid-13C2;Gamitrinib TPP;JG-98;Gedunin;Rocaglamide;Palmitic acid-13C sodium;AMP-PCP
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