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Bumetanide

CAS No. : 28395-03-1

Biological Activity：Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na⁺-K⁺-Cl⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively^[2].

Research Area：Metabolic Disease|Cardiovascular Disease

Targets：NKCC

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;FDA-Approved Drug Library;Drug Repurposing Compound Library;Anti-Cardiovascular Disease Compound Library;Anti-COVID-19 Compound Library;NMPA-Approved Drug Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;Targeted Diversity Library;Rare Diseases Drug Library;Children’s Drug Library;Human Metabolite Library;

Related Small Molecules:Sodium dichloroacetate;Azosemide

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