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BSJ-4-116
CAS No. : 2519823-34-6
Biological Activity：BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162).
Research Area：Cancer
Targets：CDK|PROTACs
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Anti-Breast Cancer Compound Library;Anti-Blood Cancer Compound Library;Targeted Diversity Library;Cancer Stem Cells Compound Library;
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;Dinaciclib;SNS-032;CC-671;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;dTAGV-1-NEG;CCT367766 formic;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;T025;HDAC6 degrader-1;Flavopiridol;CDK8-IN-3;PROTAC Axl Degrader 2;PhosTAC7;CDK9-IN-12;MS98;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX;JPS014;Eciruciclib;PROTAC PARP1 degrader;MD-224;CDK-IN-6
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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