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bpV(phen)

CAS No. : 42494-73-5

Biological Activity：bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity^[2]^[3]^[4]^[5].

Research Area：Cancer|Infection|Metabolic Disease|Inflammation/Immunology

Targets：Parasite|PTEN|Phosphatase|Apoptosis

Related Small Molecules:Physalin A;(+)-Isopulegol;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;BJE6-106;Dinaciclib;GNF362;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin

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