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Avutometinib

CAS No. : 946128-88-7

Biological Activity：Avutometinib (Ro 5126766) is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAF^V600E, CRAF, MEK, and BRAF (IC₅₀: 8.2, 56, 160 nM, and 190 nM, respectively).

Research Area：Cancer

Targets：MEK|Raf

Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;

Related Small Molecules:AZ 628;Cobimetinib racemate;EBI-1051;CHMFL-EGFR-202;Everafenib;L-779450;BI-847325;Raf inhibitor 1;MAP855;PLX-4720;RRD-251;B-Raf IN 8;RGB-286638;Binimetinib;TAK-632;Encorafenib;PD0325901-O-C2-dioxolane;RAF mutant-IN-1;AD80;CCT241161

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