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ABT-384

CAS No. : 868623-40-9

Biological Activity：ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (K_i 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD)^[2].

Research Area：Metabolic Disease|Neurological Disease

Targets：11β-HSD

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;

Related Small Molecules:BI-135585;AZD8329;(R)-BMS-816336;Carbenoxolone disodium;11β-HSD1-IN-1;Emodin-d4;HSD-016;BVT 2733;11β-HSD1-IN-6;Carbenoxolone-d4;AZD 4017;Necroptosis-IN-3;11β-HSD1-IN-11;BVT-14225;Emodin;INCB13739;AMG-221

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