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Aβ42-IN-1 free base
CAS No. : 2434633-17-5
Biological Activity：Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.
Research Area：Neurological Disease
Targets：γ-secretase
Related Small Molecules:γ-Secretase modulator 4;ELN318463;Crenigacestat;Fosciclopirox;JNJ-40418677;gamma-secretase modulator 3;γ-Secretase modulator 11 hydrochloride;γ-Secretase modulator 12;Aβ42-IN-2;DAPT (GMP);BPN-15606;LY-411575 (isomer 3);BMS 433796;YO-01027 (GMP);BI-1408;Nirogacestat dihydrobromide;gamma-secretase modulator 1 hydrochloride;MRK-560;Semagacestat;Begacestat;GSM-1;Compound E;L-685458
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