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7-Hydroxymethotrexate
CAS No. : 5939-37-7
Biological Activity：7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[2].
Research Area：Cancer|Inflammation/Immunology
Targets：Drug Metabolite
Related Small Molecules:Nicotinamide N-oxide;4-Hydroxyphenylbutazone;Ampyrone;Resveratrol-3-O-sulfate sodium;Sonidegib metabolite M48;Isonicotinic acid;Cycloguanil hydrochloride;Hydroxytanshinone IIA;Endoxifen;Fodipir;Regorafénib N-oxyde (M2)-13C,d3;AZ7550 Mesylate;AR-13324 M1 metabolite;Thyroxine sulfate;Netupitant metabolite Monohydroxy Netupitant;(-)-(E)-Guggulsterone;Leukotriene D4;Desbutyl Lumefantrine;(R)-3-Hydroxy Midostaurin;RP101442;Paeoniflorgenin;PR-104A;HMMNI-d3;Ilaprazole sulfone
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