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VU 0364439
CAS No. : 1246086-78-1
Biological Activity：VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
IC50 Value: 19.8 nM(EC50)
Target: mGluR
in vitro:
in vivo: VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Research Area：Neurological Disease
Targets：mGluR
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Peptidomimetic Library;Neurotransmitter Receptor Compound Library;
Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;VU6010572;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic acid;LY379268;AZD 9272;mGluR2 antagonist 1;ABP688;FTIDC;MPPG;L-AP3;VU6001966;VU0155041 sodium;trans-ACPD;AZD-8529 mesylate;VU 0357121;PHCCC;HexylHIBO;VU0650786
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