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Vimentin-IN-1
CAS No. : 2319587-80-7
Biological Activity：Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1.
Research Area：Cancer
Targets：Proteasome
Related Small Molecules:Calpeptin;Calpain Inhibitor VI;MG-101;ONX-0914 TFA;MG-115;UK-101;SAP2-IN-1;LXE408;GSK3494245;PR-39;20S Proteasome-IN-1;M3258;PI-1840;Rpn11-IN-1;Delanzomib;Ac-ANW-AMC;Cyclotheonellazole A;Aclacinomycin A;DD1;VR23;Tomatine;Gabexate mesylate;Alicapistat;Neurodegenerative Disorder-Targeting Compound 1
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