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Vepdegestrant
CAS No. : 2229711-68-4
Biological Activity：Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of ~2 nM.
Research Area：Cancer
Targets：Estrogen Receptor/ERR|PROTACs
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;DS20362725;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;LSD1/ER-IN-1;Giredestrant;CCT367766 formic;Avobenzone;Estriol-d3;HDAC6 degrader-1;Chrysin;PROTAC Axl Degrader 2;PhosTAC7;MS98;ERRγ Inverse Agonist 1;JPS014;(R)-DPN;PROTAC PARP1 degrader;MPP hydrochloride;MD-224;FKBP12 PROTAC dTAG-7;GPR30 agonist-1;Diethylstilbestrol;SJ10542
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