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UNC1062

CAS No. : 1350549-36-8

Biological Activity：UNC1062 is a MERTK-selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC₅₀=1.1 nM, Morrison K_i=0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC₅₀=60 nM, AXL IC₅₀=85 nM).

Research Area：Cancer

Targets：TAM Receptor

Related Small Molecules:Axl-IN-5;PROTAC Axl Degrader 2;UNC2250;R916562;XL092;Axl-IN-3;Gilteritinib-d8;Bemcentinib;Axl-IN-6;ONO-7475;RU-302;TAM-IN-2;SGI-7079;Axl-IN-8;AZ14145845;NPS-1034;Ningetinib Tosylate;UNC2541;Gilteritinib hemifumarate;UNC4203;BMS 777607;Axl-IN-7;Axl-IN-12;RU-301;TAM&Met-IN-1

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