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UC2288
CAS No. : 1394011-91-6
Biological Activity：UC2288 is a novel, cell-permeable, and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM.
Research Area：Cancer
Targets：MDM-2/p53
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Reprogramming Compound Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Transcription Factor-Targeted Library;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:MDM2-p53-IN-15;MC-VC-PABC-SP 141;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;MD-224;Mutant p53 modulator-1;MDM2/4-p53-IN-2;MX69;p-nitro-Pifithrin-α;RG7112;MMRi62;Anticancer agent 50;NSC59984;Pifithrin-β hydrobromide;Ivaltinostat formic;GEM-5;Tenovin-6;PK11007;AM-8735;GN25;RO-5963;PhiKan 083;C16-Ceramide;Pifithrin-α hydrobromide;MA242;Anticancer agent 65;CBL0137 hydrochloride;HDAC-IN-34
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