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TMPA
CAS No. : 1258275-73-8
Biological Activity：TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation[2].
Research Area：Cancer|Metabolic Disease|Inflammation/Immunology
Targets：AMPK
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Anti-diabetic Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Lipid Metabolism Compound Library ;Glucose Metabolism Compound Library;Nuclear Receptor Compound Library;
Related Small Molecules:AMPK activator 4;ZLN024;YLF-466D;BAY-3827;3α-Hydroxymogrol;HTH-01-015;AICAR;Cimiracemoside C;HL271;EB-3D;COH-SR4;AMPK activator 7;Narazaciclib;D942;MARK4 inhibitor 1;Kazinol U;Phenformin hydrochloride;Karanjin;GSK621;Dorsomorphin;Palmitelaidic Acid;PF-06685249;Flufenamic acid-d4;PF-06679142
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