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TH-257
CAS No. : 2244678-29-1
Biological Activity：TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.
Research Area：Cancer
Targets：LIM Kinase (LIMK)
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Chemical Probe Library;
Related Small Molecules:DB0614;CRT0105950;BMS-3;SM1-71;TH470;R-10015;Aurora/LIM kinase-IN-1;T56-LIMKi;RSS0680;DB1113;SR7826;BMS-5;DD-03-156
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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