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Terfenadine

CAS No. : 50679-08-8

Biological Activity：Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca²⁺ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9^[2].

Research Area：Cancer|Inflammation/Immunology|Endocrinology

Targets：Histamine Receptor|Potassium Channel|Caspase|Apoptosis|Na+/Ca2+ Exchanger

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Endocrinology Compound Library;NMPA-Approved Drug Library;Pyroptosis Compound Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Anti-Lung Cancer Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;EMA-Approved Drug Library;Potassium Channel Compound Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Kv3 modulator 2;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D

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