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TAK-960 monohydrochloride

CAS No. : 2108449-45-0

Biological Activity：TAK-960 monohydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC₅₀ of 0.8 nM. TAK-960 monohydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC₅₀s of 16.9 and 50.2 nM, respectively. TAK-960 monohydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.

Research Area：Cancer

Targets：Polo-like Kinase (PLK)

Related Small Molecules:TAK-960;Rigosertib sodium;Centrinone;HMN-176;(1E)-CFI-400437 dihydrochloride;Poloxin;PLK1-IN-2;PLK1-IN-4;MLN0905;TC-S 7005;PLK4-IN-3;SBE13 Hydrochloride;CFI-400437;Plogosertib;Volasertib;3MB-PP1;Wortmannin;PLK1/BRD4-IN-1;Poloxime;Poloppin;Cyclapolin 9;ON1231320;BI 2536

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